Introduction: Scenario-based training (SBT) is a modern, innovative teaching approach that facilitates structured discussions among nurse interns. Well-crafted scenarios are vital for educators to effectively incorporate learning objectives into the training experiences of nurse interns. Objective: This study examined the impact of scenario-based training on nurse interns’ critical thinking dispositions. Methods: A true experimental design, including the study & control groups, was utilized. The study included 120 nurse interns who were selected randomly and classified into two groups: a study group (60 NIs) and a control group (60 NIs). Data were collected using three instruments: a scenario-based knowledge instrument, a critical thinking dispositions scale, and a satisfaction tool. Results: The study results showed that there was statistically significant improvement among the study group, as 13.3% of them had a satisfactory knowledge level at preprogram (χ² = 0.323, p = .389; Cramér's V = 0.052, negligible effect). However, a very strong and statistically significant association was found both immediately after the program at 100% (χ² = 101.538, p < .001; Cramér's V = 0.920) and at the follow-up program at 98.3% (χ² = 97.634, p < .001; Cramér's V = 0.902), reflecting a large intervention effect on knowledge level. There was significant improvement postprogram in enhancing critical thinking dispositions, ranging from medium to large (Cramér's V: 0.321–0.527), as well as higher satisfaction with a percentage of 93.3%, whereas the control group did not exhibit similar increases. These gains were evident immediately after the training and were sustained at follow up, highlighting the effectiveness of SBT. Conclusion: The study determined that there was a positive correlation between SBT and the development of critical thinking dispositions in the study group postprogram implementation. The study recommended continuous assessment of teaching strategies to increase the effectiveness and efficiency of nursing education. © The Author(s) 2025. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
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